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Common side effects of Estriol include itching of the skin around the vagina, increased vaginal discharge, gall bladder problems, abdominal pain, leg cramps, . Estriol is especially helpful for skin integrity and mucous membranes. It is helpful in hormone replacement to balance estradiol side effects. Estriol can also be Without estrogen, the vaginal cells are what is called, parabasal cells. These are .